Workshops > Frontiers in Mathematical Biology

Frontiers in Mathematical Biology


Noise Attenuation and Robustness in Cell Signaling and Patterning

Qing Nie

University of California Irvine

Abstract:  

Noises and stochastic effects usually exist in every biological system due to many intrinsic and extrinsic factors. In this talk, I will discuss strategies and principles for noise attenuation and robustness to genetic or/and environmental perturbations in cell signaling and embryonic patterning. In one case, I will introduce a critical quantity that dictates capability of attenuating temporal noises in feedback systems. In another case, I will show that noises in signal transduction actually enable reduction of stochastic effects in spatial patterns. In addition, I will present several new experimental data in yeast cells and zebrafish embryo that support our modeling and computational predictions.