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Frontiers in Mathematical Biology

Application of Population Dynamics to Study Heterotypic Cell Aggregations in the Near-wall Region of a Shear Flow

Yanping Ma

Loyola Marymount University


This work focused on the modeling of polymorphonuclear neutrophils tethering to the vascular endothelial cells, and subsequential tumor cell emboliformation in a shear flow, an important process of tumor cell extravasation from the circulation during metastasis. A population balance model is utilized, which for the first time, to our best knowledge, a multiscale near-wall collision model reconciles the effect of deformation on cell coagulation procedure, and works for general ratios of heterotypic cell.